OBJECT Essays - Food And Drink, Chemistry, Fruit Juice, Biochemistry

OBJECT Essays - Food And Drink, Chemistry, Fruit Juice, Biochemistry OBJECT Inhibition of Polyphenol Oxidase activity in Apple by using some natural and synthetic anti browning agents . REQUIREMENTS Acidic fruit juices (pineapple, orange, lime, lemon ) 1% Salt solution 1% HCL solution 1% NAOH solution Tap water Apple slice s THEORY E nzymatic browning is one of the most important reactions that occur in fruits and vegetables, usually resulting in negative effects on color, taste, flavor, and nutritional value. The reaction is a consequence of phenolic compounds' oxidation by polyphenol oxidase (PPO), which triggers the generation of dark pigments. This is particularly relevant for apples, which are rich in polyphenols and highly su sceptible to enzymatic browning. In plant cells, phenolic compounds are located in the vacuoles, whereas polyphenol oxidase ( PPO) is located in plastids. Damaged areas in cells allow the contact between PPO and phenolic compounds, triggering the reaction known as enzymatic browning. Examples of beneficial enzymatic browning: Developing color and flavor in Coffee, Cocoa beans, and tea. Developing color and flavor in dried fruit such as figs and raisins. Examples of non-beneficial enzymatic browning: A non-desirable enzymatic browning reaction is involved in the formation of brown spots on the peel of bananas ,avocados,apples and potatoes Polyphenols - main components in enzymatic browning Polyphenols , also called phenolic compounds, are group of chemical substances present in plants (fruits, vegetables) which play an important role during enzymatic browning, because they are substrates for the browning-enzymes. Phenolic compoun ds are responsible for the colo r of many plants, such as apples, they are part of the taste and flavo r of beverages (apple juice, tea), and are important anti-oxidants in plants. Polyphenols are normally complex organic substances, which contain more than one phenol group (carbolic acid): Polyphenol oxidase (PPO ) Polyphenoloxidases are a class of enzymes that were first discovered in mushrooms and are widely distributed in nature. They appear to reside in the plastids and chloroplasts of plants, although freely existing in the cytoplasm of senesci ng or ripening plants. Polypheno loxidase is thought to play an important role in the resistance of plants to microbial and viral infections and to adverse climatic conditions. Polyphenoloxidase also occurs in animals and is thought to increase disease resistance in insects and crustaceans. In the presence of oxygen from air, the enzyme catalyzes the first steps in thebiochemicalconversion of phenolics to produce quinones, which undergo further polymerization to yield dark, insoluble polymers referred to as melanins . These melanin form barriers and have antimicrobial properties which prevent the spread of infection or bruis ing in plant tissues. Example of a general reaction of polyphenols by Polyphenol Oxidases that catalyzes enzymatic browning. The production of Quinones undergoes more reactions which eventually form brown pigments on the surface of fruits and vegetable. PREVENTION OF ENZYMATIC BROWNING The control of the enzymatic browning is of great importance to the horticulture industry, because this reaction occurs in many fruits and vegetables, often negatively affecting the attributes of color, taste, flavor, and nutritional value. It is estimated that more than 50% of fruit market losses ar e a result of enzymatic browning . Researchers are especially interested in studying the control (inhibition) of browning by different methods that can be employed to maximize this inhibition and ultimately pr olong the shelf l ife of commodity.Several methods can be applied to avoid enzymatic browning, based on inactivating the enzyme (heat) or by removing essential components (m ost often oxygen) from the product Blanching is a short heat treatment to destroy or inactivate enzymes before freezing of prod ucts (mainly vegetables). The enzyme activity is pH dependent. Lowering of the pH to 4.0 by the addition of citric,ascorbicor otheracidsinhibits the enzyme activity. Addition of chemical inhibitors like acidulants ,chelating agents, reducing agents may also directly react with enzyme and substrate or change the product composition . METHOD Cut one apple into small thin slices in such way that its pulp portion is exposed to our reagent . Separately place an apple slice in petri dishes and labeled them . With natural anti browning agent, in four samples out of all, squeeze some suitable amount of fresh fruit juices on apple slice. With the synthetic browning agent, firstly prepare solutions

Ed Mezvinsky, Father of the Groom - Urban Legends

Ed Mezvinsky, Father of the Groom - Urban Legends A forwarded email attributed to Cincinnati news reporter John Popovich claims that Marc Mezvinsky, Chelsea Clintons new husband, is the son of Edward Mezvinsky, a former Iowa Congressman who was convicted and sent to prison in the early 2000s for fraud. The forwarded email is correct. Description: Viral textCirculating since: August 2010Status: True (details below) Example Email contributed by James H., August 19, 2010: Subject: Birds of a featherFATHER OF THE GROOMBy: John PopovichBefore I came to Cincinnati, I was a news reporter at WOC in Davenport Iowa. I covered a lot of city council and a lot of political stuff. One of the guys I covered was Ed Mezvinsky, who was the Congressman from Iowas first district.Seemed like a pretty nice guy, but when he ditched his wife for a New York reporter, the Iowa voters ditched him.My most vivid memory is that he sat on the House Judiciary Committee that was deciding the fate of President Nixon.Anyway, years later, Fast Eddie got caught with his hand in the till. He cheated investors out of more than $10 million dollars. He went to prison for several years.This weekend, his son married Chelsea Clinton. Analysis True. On July 31, 2010, Chelsea Clinton, the daughter of former president and first lady Bill and Hillary Clinton, was married to Marc Mezvinsky, the son of a former Democratic Congressman, in a Rhinebeck, New York ceremony the press described as lavish. The father of the groom, Edward Ed Mezvinsky, who served four years in the U.S. House of Representatives from 1973 to 1977, indeed went on to serve five years in a federal penitentiary after being convicted of fraud in 2002. According to prosecutors, Mezvinsky crimes included repeatedly defrauding others by misusing attorney escrow accounts held in his name, engaging in schemes involving worthless checks deposited at banks, creating forged bank statements, using false financial statements, tax returns and accountants letters, and giving false testimony under oath. U.S. District Judge Stewart Dalzell ordered him to pay nearly $10 million in restitution to the victims of his scams. The former Congressman was contrite in an interview with the New York Post that took place in July 2010 just before the Clinton-Mezvinsky wedding. Im remorseful for what happened, he said. It was a terrible time, and I was punished for that. And I respect that and accept responsibility for what happened, and now Im trying to move on and am grateful I have the opportunity for that. For purposes of verification, I attempted to contact former Cincinnati newsman John Popovich, to whom the above text is attributed. I received no reply. Update: Chelsea Clinton and Marc Mezvinsky became parents with the birth of their first child, Charlotte Clinton Mezvinsky, on September 26, 2014. Sources and Further Reading Chelsea Clinton Marries Marc MezvinskyPeople, 31 July 2010 Chelsea Clintons Father in Law Lives Down Criminal PastNew York Post, 29 July  2010 Will Father of the Groom Be Welcome Figure at Chelsea Clintons Wedding?ABC News, 1 December 2009 Former Congressman Duped by Nigerian ScamsABC News, 8 December 2006 Mezvinsky Gets 6 Years for FraudPhiladelphia Inquirer, 10 January 2003 Last updated 06/22/15

Student Participation Essay Example | Topics and Well Written Essays - 750 words

Student Participation - Essay Example This type of passive response is self-explanatory, the students are hesitant to admit in public that they do not understand the lesson. The admission of such fact is associated with embarrassment and shame since other students would perceive that learner as slow. Unfortunately, the whole class feels that way towards themselves. Anxiety from past unpleasant experiences brought by humiliation either from teachers or fellow students is a strong motivator in keeping one’s self from actively participating in discussions. This is where the role of utilizing response cards becomes important. The learner can participate in learning by joining the group in responding to the question. The inconvenient feeling brought by anxiety is lessened since everybody is exposed when giving out an answer. The group becomes engaged in collaborative learning where nobody stands out nor left out. The first benefit of using response card is helping students overcome their anxiety when participating in class, consequently, frequent interaction that merits a positive response boosts the morale of the learner. This translates to positive reinforcement that would intrinsically motivate the student. The second benefit that response cards provide to the teaching of Math is that it acts as an effective assessment tool for the teachers. It is a common fact that students dislike types of assessment since evaluation of academic performance is always correlated with paper and pencil examination. The mere term â€Å"assessment† already gives a negative connotation for learners since it is associate with failing grades and unkindly remarks from some parents. However in the case of response cards, the students do not easily realize that an assessment is going on. The questions are viewed in a positive way by perceiving it as a challenge. Sometimes, response cards are even seen as

SELF INCRIMINATION Research Paper Example | Topics and Well Written Essays - 2000 words

SELF INCRIMINATION - Research Paper Example Two main principles of the Fifth Amendment therefore include protection of rights of persons undergoing criminal proceedings in the courts, to further support the premise of innocent until proven guilty. Secondly, the principle of prevention of prosecution conduct likely to compel defendants to give their own incriminating evidence takes shape in the Fifth Amendment. Judges cannot compel individuals before court to give information that would directly affect negatively in their pursuit of exoneration in court proceedings. Other persons with an interest in the case cannot compel the defendant to give evidence against themselves within the precincts of the court (GetLegal, 2012). The Fifth Amendment therefore controls any influence that could alter the defendant’s opportunity to present their case before court with confidence that they will not face undue pressure to incriminate themselves, thereby destroying their enjoyment of right to be innocent until proven guilty. Another emergent theme in the Fifth Amendment is the active separation of powers in criminal proceedings, where the executive faces barring environment against use of force on witnesses’ rights. The interpretation of the Fifth Amendment has however faced various contestations with regard to the parties and conditions against which the Amendment gains enforcement authen tication. In Miranda v. Arizona, a case that took place in 1966 the United States Supreme Court defined the admissibility of evidence obtained irregularly from the defendant, particularly within the conditions of absence of an attorney to guide the defendant during questioning. According to the court’s argument, obtaining exculpatory and inculpatory statement in gathering prosecutorial evidence exposes the individual to conditions that may violate their own constitutional rights of informed consent. The right against

Part IV, Current Procedural Terminology Essay Example for Free

Part IV, Current Procedural Terminology Essay This chapter provides an overview of the CPT Surgery section and covers its guidelines. The chapter also focuses on the CPT Surgery General and Integumentary System subsections. Lesson Objective Define key terms. Explain the organization, format, and content of the CPT Surgery section. Interpret CPT surgery section guidelines and modifiers. Interpret CPT surgery coding notes for the General and Integumentary System subsections. Assign CPT surgery codes from the General and Integumentary System subsections. Add CPT and/or HCPCS level II modifiers to codes as appropriate. Surgery Section Organization The Surgery section is the largest section in CPT and its subsections are organized anatomically. Selecting the appropriate surgery code requires a careful review of the patient record to determine the procedures and services provided. The basic organization of the Surgery section is by major body system, with headings and subheadings based on anatomic site and/or type of procedure. The CPT Surgical Package Definition See pages 481-482 of the 3-2-1 Code It! text; What services are always included? Read the Surgery Guidelines at the beginning of the Surgery Section in the CPT code book. Surgical Modifiers If services are provided by more than one physician, what modifiers do you use? When do you use them? Read about unusual services and treatments. What is the modifier to show unusual services? When do you use it? Find the modifier for a separate procedure. What is the definition of separate procedure? What modifier would you use to show a distinct procedural service? Integumentary System Integumentary procedures include incision, biopsy removal, paring/curettement, shaving, destruction, excision, repair, adjacent tissue rearrangements, grafts, flaps, and specialized services. Refer to the definitions of surgical terms in the textbook.

Leadership Mid Term :: Free Essay Writer

Leadership Mid Term Midterm Examination The most important thing in a group is to get the job done. Many things can help or hinder the groups overall productivity. There are three things all groups must be conscious of, group development, group think and leadership teams. All these areas determine weather a group will sink or swim, while completing the task. The first and most important is group development. Group development is something that every group must go through. It is easily explained by using Cog’s Ladder of group development, five stages of group development: Polite, why were here, bid for power, constructive, and Esprit. These stages outline the path that all groups go through to form their identity. The way your group develops can often determine your actions and your comparative status amongst the other group members. (notes) The first stage is POLITE this happens when you are first placed into a group, everyone is trying to avoid conflict. All people in this stage just want to be liked and feel accepted in the group. The next stage is WHY WERE HERE when the group actually takes a look at the task in front of them. People a generally nice to each other -- a time of exploration. Third is the BID FOR POWER Cliques battle individuals in the attempt to impose their ideas on the rest of the group. This is a time of much confusion amongst group members as they try to find out who is the best person to take orders from. The next stage is the CONSTRUCTIVE stage. In this stage there is a huge attitude change and people begin to give up their need for power and start concentrating on their goal. At this point there are many offered solutions by all group members. The last stage is Esprit here there is a lot of high moral and group loyalty. In this stage the group is tight, they have over looked personal differenc es, completely focusing on the task. An outsider at this point has the potential of destroying the well developed group. (notes) When forming a group it is important to include everyone right off the bat. Receiving good input from everyone is key to group development. Everyone in the group must respect and get along with the other members in order to provide substantial progress. Groupthink is a trap that all groups must attempt to avoid.

Mid term Exam

1. a. Opportunity cost is the cost of the foregone alternative.   It is the cost incurred for net selecting a particular course of action.   Opportunity cost is present in a lot of areas in economics, such as labor and capital.b. Increasing costs are expenditure that rises due to a particular activity.   For instance, if the economy is growing and the disposable income of the population is increasing, the velocity of circulation of money will rise.   This will eventually lead to increasing costs.c. Unemployment basically comprises the part of labor, which is capable of working, but which presently is not employed.   Unemployment arises when the actual output of the economy is lower the potential gross national product.d. Scarcity arises whenever the quantity supplied does not meet the quantity demanded for a product or service.   Scarcity can also apply for labor supply, in instances, where the economy is growing at a fast rate, but there is not sufficient labor to accomm odate the job vacancies needed.2. a. Chicken is a substitute product of beef.   Therefore the rise in price of chicken will lead to a rise in the demand of beef leading to an outward shift of the quantity demanded.b. If the wages of meat cutters will increase, more individuals would be interested in working in that area.   Therefore the quantity supplied of meet would increase leading to an outward shift in the quantity supplied.c. As income increases the disposable income of the population will rise.   If meet is considered a luxury good, the quantity demanded will rise because more will be afforded.   As a result an outward shift in quantity demanded will arise.d. If import quotas are eliminated, the competition and supply of beef will increase.   This will lead to a surplus in the market, which will eventually direct to a lower demand.   An inward shift of the quantity demanded will thus arise.3. If for instance, the availability of cows diminishes due to an epidemic disease on cows.   This will direct to a leftward shift in the quantity supplied resulting in the quantity supplied not meeting the quantity demanded.   This shortage of meet, will eventually lead to a shift in the demand curve to reach again equilibrium position at a higher price.   The level of employment will be enhanced due to more number of firms willing to enter the market.   However, such shortage may limit the availability of meet supply.On the contrary if competition is increased in the market of beef, due to a reduction/removal in import quotas or new entry of firms, the quantity demanded will shrink through an inward shift.   This will thus lead to a quantity supplied greater than quantity demanded.   Therefore there will be a surplus of meet supplied that will direct a shift in the quantity supplied to meet again equilibrium at a lower price.   Firms will eventually drop out of the market due to lower profits leading to a decrease in the level of employment in such industry.4. The total utility of a client is maximized when the marginal utility of a commodity is equal to the marginal utility of the other good.   Indeed the indifference curve is a graph that portrays a combination of commodities with the same level of utility.   Points are inputted from the situation at hand, which are eventually connected to form an indifference curve graph.   This holds on the assumption that consumption of goods is varied continuously and not incrementally.5. a. Price elasticity of demand is a measure of the level of responsiveness of the quantity demanded to changes in price.   Price elasticity of demand is not the demand curve.b. The income of an individual is an important determinant of demand.   Income elasticity of demand is a calculation that shows the sensitivity of demand in relation to changes in income.c. In the real world a manager should not isolate on the price of the product or service sold only, he should also consider the p rices of substitute and complementary products and services.   In this respect cross-price elasticity of demand is used to calculate the responsiveness of demand of the product marketed in relation to changes in prices of substitute or complementary products.d. Price elasticity of supply also is a determination of the level of responsiveness of the quantity supplied to movements in price.6. The price elasticity of demand is the effect that a change in a variable will hold on the other variable.   A coefficient price elasticity of demand equal to 1 is attained for a unitary elasticity, one greater than 1 for an elastic demand and one less than 1 for an inelastic demand.   Under unitary elasticity, a percentage change in price will exactly provide the same effect on the quantity demanded.   Therefore a one percent increase in price will lead to a one percent decrease in quantity demanded.An elastic demand is an instance where a change in price leads to a more than proportionat e effect on quantity demanded.   Thus a one percent increase in price will lead to a decrease in demand greater than one percent.   On the contrary, under inelastic demand a change in price will lead to a less than proportionate change in quantity demanded.   So a one percent increase in price will direct to a less than one percent decrease in quantity demanded.7. Under an elastic demand total revenue would decrease when the price rises.   This is due to the fact that the increase in price will be exceeded by the reduction in units demanded due such elasticity.   For instance a product that holds a price elasticity of demand of 5.   If the present demand is 100 units and the actual price is $5, the total revenue is $500.If a 1% rise in price occurs increasing it to $5.05 a fall of 5% in demand will occur direct sales to 95 units.   In this case the total revenue would amount to $479.75, which is lower than the original revenue.   On the contrary, under an inelastic d emand a rise in price will direct to higher revenue since the percentage decrease in units sold would be less than the percentage increase in price.8. The cross-price elasticity of demand for substitute goods is always positive because the price of one item and the demand of the other move always in the same direction.   For example, chicken and meat are substitute goods.   If the price of chicken will rise, the quantity demanded for meat will increase too, because clients will shift from buying chicken to meat.The cross-price elasticity of demand for complimentary goods, on the other hand, is always negative because the price and quantity demanded of the variables at hand move at the opposite direction.   For instance, cameras and films are complimentary.   If the price of films increase, the demand for cameras will fall because fewer customers will purchase cameras in light of additional costs incurred for films, which are necessary for the camera to take photos.9. The fir st and most important is the availability of substitutes.   The more a product or service faces substitute products, the more price-elastic is the demand.   This is due to the fact that if there are close substitutes and the price of the product is increased, the customer will shift to the substitute product and therefore the demand for the commodity will decrease.   For example, if the price of laptop computers were to rise, the demand for such product will probably fall because people will shift to personal computers.It is important to note that the effect of substitutes highly depends on how ‘substitute products’ are defined.   Usually the more specific the definition the higher the number of substitute products.   For instance, if the example of laptop computers were to be lessened to laptop computers of Hewlett Packard, one would find more substitute products like laptop computers of other competing companies, leading to a greater price-elastic demand.The income spent on the product is another determinant of price elasticity of demand.   The higher the income spent on the commodity, the more elastic is the demand.   For example, goods like bread, pepper, and sugar tend to have an inelastic demand curve, because they make up a low amount of the consumer’s budget.While products like cars have a more elastic demand curve due to the fact that people are more cost conscious when products are of a high value and therefore are more affected by changes in price.   However, in practice it is not guaranteed that the hypothesis mentioned in this paragraph actually takes place.   Indeed, some economists weaken the theoretical relationship that exists between the proportion of income spent on the product and the price elasticity of demand.Time element also places significant influence on price elasticity of demand.   The longer the time period, the more price-elastic is the demand, because substitute goods will be adapted or cre ated to cater for the change in price.   For example, if the price of electricity were to increase drastically during the passage of time people will replace their home equipment and appliances to consume less electricity.For instance they may adopt a solar geezer or replace their electric cooker with a gas cooker.   On the contrary, the price elasticity of demand of durable goods behaves in the opposite direction.   For durable goods like cars, the responsiveness of demand to price movements weakens with the passage of time.   This is primarily due that in the long run old cars wear out and clients are forced to replace such vehicles if they intend to remain in the same product category.10. Returns to scale are a production technique that considers how a proportionate increase in factors of production will affect total production output.   There are three stages of return to scale, being constant, increasing and decreasing.   Management should reach the highest point of the increasing returns to scale, where output rises in a higher proportion than input.   Economies of scale are more a cost concept, which examines the effect of production on costs through labor specialization and other technical factors.   The information portrayed below show the costs of production for a particular product.As we can see the higher number of units produced per worker is at 4 employees.   After that a diminishing return to scale will arise.   This coincides to the attainment of economies of scale, where the additional cost per new employee is at its lowest by $1.   In this respect returns to scale and economies of scale are related in the sense they normally correspond with each other.   Indeed, economies of scale normally aid the organization in attaining increasing returns to scale.11. Short-run is considered as any time frame in which there is at least one factor of production that cannot be altered and is considered to be fixed.   In the long run all factors of production are variable and can be altered.   In order to remain operative in the short run a firm ought to cover all the variable costs.   Fixed costs at this stage are considered as sunk costs because they cannot be altered and will not affect the going concern decision.12. Explicit costs are costs that involve a cash outflow of money, while implicit costs are expenditure that does not involve cash payments, such as depreciation.13. The economic concept of profit is based on theoretical constructs.   Originally such concept focused on the difference between revenue and expenditure, being the surplus needed to maintain the capital of the firm.   The economic cost of production for a firm was regarded as the opportunity cost of production.With respect to the accounting concept of profit, one must consider the fact that originally the accounting concept of profit was similar to nowadays-economic concept of profit.   Indeed at the origination of this concept accountants regarded profit from a balance sheet perspective.   However during the passage of time accounting profit shifted to a matching of revenues and costs consumed in a particular period of time.   Accountants contend that such shift developed through the evolution of business enterprises, from a fully liquid business enterprise to large public limited companies.14. a. A firm made Sales revenue of $10,000 and revenue expenditure amounted to $9,000.   Equipment of $10,000 was bought and the present interest rate is 10%.   The accounting profit is $1,000, while there is no economic profit since an opportunity cost of capital of $1,000 is deducted with respect to the foregone money due to the equipment bought.b. A firm made Sales revenue of $12,000 and revenue expenditure amounted to $8,000.   Equipment of $12,000 was bought and the present interest rate is 10%.   The accounting profit is $4,000, while the economic profit is $2,800.c. A firm made Sales revenue of $9,0 00 and revenue expenditure amounted to $7,500.   Equipment of $20,000 was bought and the present interest rate is 10%.   The accounting profit is $1,500, while the economic loss amounts to $500.d. As regards example b, the company is attaining economic rent and will thus continue operating.   Under perfect competition new firms will enter this market in the long term.   In case c, the firm will get out of the market due to an economic loss.   As regards example a, a normal profit is attaining, implying that the market is at an equilibrium and under perfect competition no firms will enter or exit the market. References:Hirschey M.; Pappas J. (1995). Fundamentals of Managerial Economics. Fifth Edition. New York: The Dryden Press.Maunders P.; Myers D.; Wall N.; Miller L. (1993). Economics Explained. Second Edition. London: Collins Educational.

Dinner With Friends

Within the field of psychology there are branches that explore different types of human behaviour. Some of those branches turn their attention to hidden aspects of the human nature, like for example research into our linguistic faculties, other deal with modeling of various situations to better investigate our individual or group modes of action.But perhaps one of the fields of psychology that deals with the realm of human life which is most familiar to us in our everyday goings-on is the branch investigating interpersonal communication. Interpersonal communication can be most generally defined as our communication with another person or within a group of persons. However, this overall description hides the true complexity and variety of the forms that interpersonal communication can take.Indeed, to this aspect of our social life we can attribute such fundamental elements of out interaction with people as ability to initiate and maintain conversations or arguments, to listen, to spea k privately and publicly, to generate and interpret patterns of nonverbal communication, manifest our unconscious modes of communication, and any other skills that actually enable us to be active members of society. At this point, considering the proximity of the phenomenon of interpersonal communication to our everyday life, we may wonder what are the proper ways of study of forms of interpersonal communication?Of course, psychology as a strict science has its own standards and methods of investigation. But at the same time I think that we can find a lot of examples of interpersonal communication happening on a regular basis right before our eyes. To see this we may turn to the film â€Å"Dinner With Friends† (2001) directed by Norman Jewison, which provides a lot of interesting aspects relevant to the theory of interpersonal communication. Let us take a closer look and discuss such aspects.The film â€Å"Dinner With Friends† tells a story of two married couples †“ Gabe and Karen, and Beth and Tom – that have been close friends for 12 years, and were spending their time over dinners discussing their relationships, their children, and other matters and interests that friends can share. However, when unexpectedly for Gabe and Karen Beth declares that she and Tom had decided to separate, this event inflicts a profound change in the pattern of their relationships.As both couples undergo emotional turmoils it turns out that, ironically, their mutual love of cooking may be the only thing that remains between them, while their former friendship is gone. â€Å"Dinner with Friends† is mostly built upon conversations as the vehicle to unfold the story. The personages talk a lot about different things, from their love of food to their ideas about the meaning of life, and the director managed to make dialogues in the film very life-like, akin to those that we would expect from really good friends.In this way, touching upon the theme of t he complexity of human relations that is familiar and important to most of us, the film provides very subtle insights into the nuances of friendship, marriage as a very delicate union between people, and divorce as a force that can have profound impact on lives of people. Now, speaking about interpersonal communication we may immediately begin to find examples of it in the film.Being the direct and the most personal form of interaction, interpersonal communication helps people learn about each other in an intimate way. We can see this in the film, which depicts communication between two people, also called dyadic communication. Dyadic communication occurs in privacy between Gabe and Karen, and Beth and Tom, and also between Karen and Beth, and Tom and Gabe, when due to the break-up of their traditional relations tensions develop between these women and men.In this regard, it is interesting to point out that as Gabe and Karen perceived their friendship with Beth and Tom as a close on e, after learning about the alleged betrayal of Beth by Tom Karen is angry that she had been unaware of the brewing troubles in their marriage. Thus, the previous apparent intimacy of relations between the couples was not completely true, and it could hardly be such. As Karen bitterly says, one can spend the whole life with another person, and in the end it may turn out that the person you fully entrusted your fate to is an impostor.To this, Gabe thoughtfully responds: â€Å"But it can`t be as simple as that†. Indeed, in accordance with the developmental view of interpersonal communication, with time communicators get to know more details about each another, develop ability to partly predict their behavior, and create their own rules of communication. But in the case of the couples from the movie, it seems that their established rules of communication at some point began to lag behind the changing nature of relationships within couples themselves, as most notably was the case with Beth and Tom.At the same time, being influenced and disturbed by the divorce of friends Gabe and Karen also had to reevaluate their seemingly healthy marriage. This fact hints about another quality of interpersonal communication, which lies in its effect on formation of our self-concepts through confirmation and gradual transformation of our identities. In application to the characters from the film, this can be evidenced by the belief of Gabe and Karen that they knew their friends very well, while in reality this was not the case.And when tensions between couples develop, Beth reevaluates the nature of gifts that Karen, who considered Beth to be â€Å"a mess†, had presented to her. In the scene where Beth declares that she has a new lover and Karen advises her to slow down, Beth observes: â€Å". . . you love it when I'm a mess. Every Karen needs a Beth. † It is not wonder that such aggressive stance of the person who had been your close friend can surely influe nce our self-perception. We also may interpret the interrelations between the characters of the film as representative of the small group communication aspect of interpersonal communication.While it is somewhat difficult to define a small group, some researches propose to consider as small such a group in which each participant can immediately sense and remember the presence of other participants. This definition suits the situations of the personages of the film â€Å"Dinner With Friends† very well. Judging from this viewpoint, small group communication between the couples can be interpreted as a dynamical process of receiving inputs, processing the information, and outputting certain behavioral modes.Input factors are present even before a group forms, and in our case it is the mutual background of the two couples, as Beth and Tom were in the first place introduced to each other by Gabe and Karen; process factors are developments that emerge in the process of communication within group, as exemplified in the film by rapid change of the format of individual relations between the personages themselves, and, consequently, between the couples in the aftermath of the break-up between Beth and Tom; finally, output factors are end results of the communication, and for Gabe, Karen, Beth, and Tom the end results were different, but in all cases prominent.For Beth and Tom the divorce meant the transformation of their lives, and for Gabe and Karen the separation of their friends from their small group serves as an impetus to come to conscious conclusion that â€Å"practical matters outweigh abandon† when it comes to their own family chores. On ground of what we have discussed, we can see that in the end of the film all its personages are deeply affected by the changes in the disposition of their dyadic relations and relations within their small group. In this way, it becomes clear that interpersonal communication has a very important role for all of us be cause it can influence the most important aspects of our life, friendship and marriage among them.

The role of ApoE and its isoforms in Alzheimer’s disease The WritePass Journal

The role of ApoE and its isoforms in Alzheimer’s disease The role of ApoE and its isoforms in Alzheimer’s disease IntroductionThe ApoE gene (Physiological Functions)The ApoE isomersApoE AÃŽ ² Aggregation (Fibrillogenesis)AÃŽ ² Clearance by ApoE ApoE and Neuronal InflammationConclusionBibliographyRelated Introduction Research into the genetic causes of Alzheimer’s disease have progressed considerably and currently at least three different genes are known to be linked with AD pathogenesis. Of these the apolipoprotein gene E (APOE), an amino acid glycoprotein, is one of the main focus of research over the last decade or so and significant associations between one particular isoform of the gene and the onset of AD have been reported. This isomer, referred to as the ApoE 4 allele, has been implicated in AD pathogenesis while other forms of the gene the ApoE 2 and the ApoE 3 have been reported to have a protective effect against the onset of AD. Though research has confirmed this variable effect of the different forms of the ApoE gene, there is still a lack of concrete evidence as to the exact pathway and the mechanism by which ApoE 4 contributes to neurodegeneration in AD patients.   A brief review of related research would provide us more insight into the various pathological actions of Apo E 4 and how these multiple factors could lead to a gradual cognitive decline which is symptomatic in Alzheimer’s patients. The ApoE gene (Physiological Functions) ApoE is an amino acid glycoprotein that is found mainly in the liver and the brain. In the brain, ApoE is predominantly secreted by the astrocytes. Two other forms of apolipoproteins namely ApoA-1 and ApoJ are also found in the brain. In vitro studies of these two genes have so far suggested that both of them exhibit a neuroprotective effect. Both these proteins bind to AÃŽ ² and therefore are thought to reduce AÃŽ ² aggregation in the brain which is a known marker of AD.   However, in vivo studies have not replicated such results and so the protective roles of ApoA-1 and ApoJ are not yet clear.   The ApoE supports cholesterol equilibrium by serving as a ligand during endocytosis of lipoprotein particles by LDL receptors. Research is divided in the opinion that the cholesterol released from ApoE mediated endocytosis process is actually used for improving the synaptic connections or the synaptic plasticity. Mice based in vivo studies have not attested to this synaptogenesis. (Kim et.al, 2009) The ApoE isomers Three single nucleotide polymorphisms of the ApoE gene are commonly identified in humans. These are the apoE2 (cys112, cys158), apoE3 (cys112, arg158), and apoE4 (arg112, arg158) respectively. (Kim et.al, 2009) The structural and functional aspects of the three isomers of ApoE are totally altered though they differ by only one or two amino acid positions.   Studies have reported strong immune-reactivity of the human apoE4 gene on amyloid plagues and the apoE4 isomer has been associated with having a strongest risk factor for AD. Some studies such as (Bertram et al., 2007) and (Bertram et al., 2009) have attested to this role of the apoE4 isomer in AD.   Bertram et al., 2009 for instance reported that people with a single copy of the apoE4 gene had a three fold increase in risk for AD, while the   risk was 12 fold among those with a dual copy of the ApoE4 gene.   The results from studies also suggest the possible role of some environmental factors as research based on some eth nic groups have revealed that the ApoE 4 gene does not have a significant effect on AD. ApoE AÃŽ ² Aggregation (Fibrillogenesis) Several research studies have focused upon the potential role of ApoE 4 in causing AÃŽ ² aggregation and neuronal degeneration. This direct interaction between the ApoE 4 with beta amyloid is attributed in the pathogenesis of the disease. Therefore it was hypothesized that increased levels of ApoE 4 in the brain corresponded to increased formation and thickness of amyloid plaques. The findings from one comprehensive study by Tiraboschi et.al (2004) validated this hypothesis. The researchers in this study confirmed increased plaque density corresponding to increased levels of ApoE 4. This positive association was again confirmed by a more recent study by Reiman et.al (2009). The researchers of this study used an amyloid detecting agent such as Pittsburgh compound B (PIB) along with positron emission tomography to detect the levels of fibrillar AÃŽ ² in the subjects. The researchers then correlated this information among individuals with varied genetic risks. The results from the study clearly revealed that ApoE 4 homozygotes had the highest risk (91%) for developing AD while ApoE 4 heterozygotes had a moderate risk of 47% and finally ApoE 4 non carriers had only 20% risk of having AD. Furthermore, the mean age of onset of AD was also vastly different with ApoE 4 homozygotes at 64, heterozygotes at 76 and 84 years of age among non carriers.   This longitudinal study clearly provides positive evidence connecting the ApoE 4 gene with a high risk for AD.   Thus there is enough evidence that ApoE 4 gene may aid in ï ¬ brillogenesis and consequent cognitive decli ne. (Reiman et.al 2009). AÃŽ ² Clearance by ApoE Some studies have shown that ApoE by binding with soluble AÃŽ ² promotes the cellular uptake and ingestion of the ApoE –AÃŽ ² complex   Ã‚  by endocytosis.   However, isomer specific results for this ApoE facilitated cellular uptake of AÃŽ ² are still awaited.   Research has also focused on the possible clearance of   AÃŽ ² from the brain via the blood brain barrier. However, there is growing evidence that ApoE 4 might actually hinder or reduce this clearance of AÃŽ ².   Deane et.al (2008), a study based on mice reported that the clearance rate of ApoE 4 –AÃŽ ² complex is much lower than that for the ApoE2 and ApoE 3 complexes. Other recent studies such as Bell et.al (2007) and Ito et.al (2007) that focused on studying the AÃŽ ² clearance in humans found that the clearance rate along the Blood Brain Barrier (BBB) was significantly lower for the ApoE 4 –AÃŽ ² complex compared to that of simple AÃŽ ² peptides.   These studies offer enough evidence that ApoE 4 might actually increase the fibrillogenesis by directly affecting the AÃŽ ² metabolism in the brain. By reducing the clearance rate and promoting aggregation ApoE 4 gene definitely poses an increased risk factor for AD. ApoE and Neuronal Inflammation Several studies have reported that ApoE has marked anti inflammatory properties which explain the surge in their production in the aftermath of an injury. These studies hypothesize that ApoE is needed for maintaining the cholesterol homeostasis, and in particular for increasing the availability of cholesterol for neuronal repair and improving the synaptic plasticity subsequent to brain injury. (Slezak Pfriege, 2003 ). However studies have also reported differences in neurite growth and synaptic plasticity post neuronal insult in animal studies based on the genotype.   One transgenic mice study found that neuronal growth and synaptogenesis were markedly lower among ApoE 4 transgenic mice compared to ApoE3 transgenic mice. (White et.al, 2001) An extensive review of the neuroprotective effects of the various ApoE isomers by (Cambon et al, 2000) clearly showed differential effects between the isomers. Most of the studies reported that ApoE3 promoted synaptic plasticity and neurite gro wth. However similar positive results were not witnessed in the case of ApoE 4 alleles with some studies even reporting the negative effects of ApoE 4 on synaptic plasticity and neuronal growth.   Colton et.al (2004) found that the anti-inflammatory effects vary drastically between the ApoE isomers.   The researchers studied this variability in anti-inflammatory response triggered by the ApoE 3 and ApoE4 isomers by using in vivo experiment conducted on ApoE knockin mice. By studying Lipopolysaccharide (LPS) mediated inflammatory responses the researchers observed the differences between the isomers. The inflammatory response was much greater in the ApoE 4 knockin mice when compared to the ApoE3 Knockin mice. These studies suggest that the anti inflammatory response maybe less active in ApoE 4 and this might lead to neuronal damage as witnessed in AD patients.  Ã‚   (Kim et.al, 2009) Conclusion The review of studies has revealed that the ApoE isomers have differential effects on the AÃŽ ² metabolism in the brain. While the ApoE 2 and ApoE 3 isomers have been reported for their protective effects the ApoE 4 allele clearly seems to contribute to the AD pathogenesis. Results from recent fibrillar PET imaging studies suggest a clear positive correlation between the ApoE 4 allele and the density of amyloid plaque formation. It is clear that by slowing down clearance of AÃŽ ² as well as contributing to its aggregation in the brain, the ApoE 4 allele increases the susceptibility of a person for AD. It is also possible that the ApoE 4 also lowers the protective function by increasing the neuronal inflammatory response and by hindering neurite growth. More studies are necessary to understand the complex relationship between ApoE and AÃŽ ² and the levels of different isomers of ApoE and their corresponding impact on Neuroinflammation and neurotoxicity, etc. Bibliography Jungsu Kim, Jacob M. Basak, David M. Holtzman, (Aug 13th 2009), The Role of Apolipoprotein E in Alzheimer’s disease, Neuron 63. Bertram, L., McQueen, M.B., Mullin, K., Blacker, D., and Tanzi, R.E. (2007) Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat. Genet. 39, 17–23. Bertram, L., McQueen, M.B., Mullin, K., Blacker, D., and Tanzi, R.E. (2009). The AlzGene Database Alzheimer Research Forum available at, alzgene.org. Eric M. Reiman, Kewei Chen,Xiaofen Liu et.al (Apr 2009), Fibrillar amyloid-ÃŽ ² burden in cognitively normal people at 3 levels of genetic risk for Alzheimers disease, Proc Natl Acad Sci U S A.  ;  106(16): 6820–6825. Bell, R.D., Sagare, A.P., Friedman, A.E., Bedi et.al (2007). Transport pathways for clearance of human Alzheimer’s amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. J. Cereb. Blood Flow Metab. 27, 909–918. Ito, S., Ohtsuki, S., Kamiie, J., Nezu, Y., and Terasaki, T. (2007). Cerebral clearance of human amyloid-beta peptide (1-40) across the blood-brain barrier is reduced by self-aggregation and formation of low-density lipoprotein receptor-related protein-1 ligand complexes. J. Neurochem. 103, 2482–2490 Part 2 Fibrillar amyloid-ÃŽ ² burden in cognitively normal people at 3 levels of genetic risk for Alzheimers disease   (Reiman et.al 2009) This research study by Reiman et.al (2009) hypothesized that fibrillar amyloid accumulation is an early development in the onset of Alzheimer’s disease.   The researchers further hypothesized that the fibrillar amyloid accumulation precedes any recognizable symptoms of cognitive decline. Amyloid plaques are a distinct feature of AD as observed from post mortem studies. Given the hypothesis that fibrillar AÃŽ ² accumulation is observed even in healthy, non symptomatic adults, the researchers intended to study the effect of fibrillar AÃŽ ² burden as a predictor of future onset of AD on adults with normal cognitive function using Ante mortem  brain imaging studies. For this study, the researchers used Pittsburgh Compound B (PiB), a radio ligand that binds only with the fibrillar AÃŽ ² species. Earlier studies have also used this PIB for imaging studies of live human brain to observe the formation of fibrillar AÃŽ ² in healthy adults. This study by the authors is aimed to extend the previous studies by providing a genetic risk analysis and to understand the predisposition to AD based on an individuals APOE genotype. The APOE genotypes were identified by using blood sample analysis. The researchers used fluorodeoxyglucose PET, volumetric MRI and neuropsychological tests. Fibrillar imaging was done using 3 dimensional HR+ scanner.   The subjects of this study were all cognitively normal and late middle aged people representing a mixture of APOE genotypes. This was a longitudinal study and the subjects were assessed every 2 years. The researchers observed that cerebral glucose metabolism levels of those subjects carrying dual copy of the ApoE 4 (homozygotes) was significantly lower than that of the heterozygotes and the non carriers. With the PiB Pet images the researchers compared and correlated the fibrillar burden with the genetic risk to understand the predisposition for AD between the various isomers. The average Pittsburgh(PiB) distribution volume rations(DVR), which is a measure of the fibrillar AÃŽ ² accumulation, was on increase in all the three different groups in the 2 years period. One of the homozygote subjects developed mild amnesia and her DVR was close to that of an AD patient. Overall of all the 28 subjects (8 homozygotes, 8 heterozygotes and 12 non carriers), the ROI measurements pertaining to the different brain regions such as temporal, parietal, posterior cingulate-precuneus, basal ganglia, etc, was the highest among the homozygotes. The researchers used statistical analysis and found that the homozygotes had considerably higher ROI values when compared to the non carriers (P   .05) while the difference between the heterozygotes and the non carriers was not significant (.05   P   .11). When correlated the APOE4 and Fibrillar AÃŽ ² burden was found to be significant among both homozygotes and heterozygotes compared with the non carriers. The study authors successfully found that even in cognitively normal individuals there is a positive correlation between ApoE 4 and fibrillar AÃŽ ². The results from the study suggest that the ApoE 4 is clearly associated with increased AÃŽ ² aggregation and decreased AÃŽ ² clearance. The following PET map clearly indicates the various regions of the brain that are affected by AÃŽ ² accumulation. Group A represents the homozygotes while group B and C represent the heterozygotes and non carriers respectively. Longitudinal studies are very effective in following the growth of fibrillar AÃŽ ² accumulation as they provide a clear pattern of disease progression even in the asymptomatic stage. People who are in late middle age who are at risk for AD would greatly benefit from a prophylactic intervention based on the brain mapping study and their ApoE genotype. This study clearly contributes to our understanding that the ApoE 4 is directly involved in the AÃŽ ² interaction and the formation of Amyloid Plaques. By considering live brain images for the study the authors were able to clearly confirm the association between the ApoE 4 and AÃŽ ² fibrillar density and predict the increased susceptibility of people with that genotype. This study has large implications for the treatment of AD. By proving that AÃŽ ² fibrillar formation precedes a perceivable cognitive decline, this study recommends early interventions particularly for people with ApoE 4 genotype, as the current AÃŽ ² modifying treatments would be more effective before extensive AÃŽ ² accumulation has occurred. The researchers advocate the use of brain imaging studies combined with genotype based risk assessment as a potentially powerful tool in preventive therapy for people who are at a genetically high risk for AD. One of the drawbacks of the study is the very small study sample. A large cohort based longitudinal study would have provided more conclusive confirmation of the study results. Bibliography Eric M. Reiman, Kewei Chen,Xiaofen Liu et.al (Apr 2009), Fibrillar amyloid-ÃŽ ² burden in cognitively normal people at 3 levels of genetic risk for Alzheimers disease, Proc Natl Acad Sci U S A.  ;  106(16): 6820–6825.

The Comparative and Superlative Forms of Adjectives

The Comparative and Superlative Forms of Adjectives This exercise will give you practice in effectively using the comparative and superlative forms of adjectives. InstructionsComplete each sentence below with the appropriate comparative or superlative form of the adjective in italics. When youre done, compare your answers with those on page two. Her voice, which was always soft and melodious, was even _____ and sweeter than usual.All four boys were uncommonly lazy, but Jimbo was the _____ of them all.Of all the silly things people said toward the end of the twentieth century, perhaps the _____ came from the author who declared the end of history. Bright stars filled the night sky, but there was one star that was larger and _____ than the others.A loud voice is needed to command attention, but the _____ voice in the room seldom belongs to the most effective leader.Working in a library may not seem very interesting to most people, but Maggie believed that she had the _____ job in the world.My grandpa told a good joke, but I told a _____ one.Our final exam was difficult, far _____ than I had expected.Terry went directly to the shelf filled with cheap toys and picked out the _____ one he could find.Andrew didnt think the joke was very funny, but after Karen explained it, he laughed like it was the _____ joke he had ever heard.I made up a story about a beautiful bird that sang the _____ song ever heard. Gandalf says that the ring is dangerous, far _____ than anyone can imagine.You own many ugly sweaters, but this one has to be the _____ sweater in the world. Below (in bold) are the answers to the Exercise in Using the Comparative and Superlative Forms of Adjectives. Her voice, which was always soft and melodious, was even softer and sweeter than usual.All four boys were uncommonly lazy, but Jimbo was the laziest of them all.Of all the silly things people said toward the end of the twentieth century, perhaps the silliest came from the author who declared the end of history.Bright stars filled the night sky, but there was one star that was larger and brighter than the others.A loud voice is needed to command attention, but the loudest voice seldom belongs to the most effective leader.Working in a library may not seem very interesting to most people, but Maggie believed that she had the most interesting job in the world.My grandpa told a good joke, but I told a better one.Our final exam was difficult, far more difficult than I had expected.Terry went directly to the shelf filled with cheap toys and picked out the cheapest one he could find.Andrew didnt think the joke was very funny, but after Karen explained it, he laughed like it was the funniest joke he had ever heard. I made up a story about a beautiful bird that sang the most beautiful song ever heard.Gandalf says that the ring is dangerous, far more dangerous than anyone can imagine.You own many  ugly  sweaters, but this one has to be the ugliest sweater in the world.

Summary of Articles Assignment Example | Topics and Well Written Essays - 5000 words

Summary of Articles - Assignment Example which impact on the establishment of intervention needs for infants with torticollis include: presence of torticollis itself, absence of improvement with current treatment, limitation of range of motion, palpable mass of sternocleidomastoid, maintaining head and body positions, developmental delays, feeding problems, parental concerns, and resources available. Intervention needs of infants with this condition are complicated. Applying holistic approach by the therapists based on ICF-CY would assist in ensuring quality of care. There were different workloads within hospital sites and fields. Objectives on attention functions as well as transferring were related to support of neurological and musculoskeletal conditions. The study revealed that to some extent, these elements can impact and determine therapy workload for hospitals (1) Among inpatient clients, their objective is to accomplish activities and ensure participation; for the outpatients, they are focused on ensuring the balance of activities and taking part in body functions. During therapy sessions, the two groups are focused on ensuring bodily functions as well as structures (1). The physiotherapists used current methods in the individualized treatments. They also included different ideas from other available methods. In the assessment and outcome evaluation, body function activities were mostly applied. (1) The ICF domains which usually were considered significant for respondents were on mobility, self-care, as well as communication. Unimportant domains included spare time, learning, and thinking, as well as domestic life. There were no differences observed for participant groups. Statistical differences were however noted in relation to spare activities, communication, and mobility. To establish if the clinical evaluation carried out by physiotherapy students on children with neurological conditions can be improved with the application of the International Classification of Functioning,

To what extent the principle of contract has been applied in the Essay

To what extent the principle of contract has been applied in the design of the Contract law in China - Essay Example Moreover it is a legal document and is directly under the law and any deviance from the agreement or the contract can lead to severe punishment by the law. The government has a direct involvement in the contract and any deviation may lead to serious consequences. A contract in general consists of an offer, the act of accommodating to the offer and a valid and valued consideration over the agreement. By means of signing of the contract each party gains certain rights and duties over the other parties involved in the contract. The amount of benefit received by the parties is not necessarily of the same amount, one of the party can gain more benefits than the other part but the other part cannot raise any voice if the part has already signed the contract; because signing the contract means that both the parties have accepted all the points of the contract and after the signing process no arguments can be raised. The most important thing in a contract is that it is done by mutual approva l and sanction (China, 1999). The Republic of China for its people has introduced the contract law for the protection of rights and to provide them with a sense of strength and independence. The government has enforced certain laws regarding the issue of contracts and the laws have been designed so that during the process of contract or agreement signing the weak party or person cannot suffer from any lose or come under the pressure of the powerful party, person or organization. The law also states that no party or person can be forced to sign a contract or to withdraw from any contract. Each and every citizen of the country has been given the full right to enter or leave a contract on their wish. The most important issue that is discussed in the law is that the contract points must be entirely based on honesty, justice, and equity and the rights of the people must always be kept under consideration. It is a binding on the parties or individuals involved in the contract that whateve r agreement takes place in the contract, it must be taken place by the mutual consent of both the parties and no individual person or party of the contract will have the power to make any changes or amendments without the consent of the other party (China, 1999). It is a binding on the parties of the contract to strictly observe the points of the contract accordingly. One very important point for the contract enforcement is that both the parties have their signatures on the contract and this signature process must be performed within a certain time period. If the time limit exceeds then the contract will no longer remain valid and applicable and will have to be renewed from the beginning. There is a possibility that the other party signs the contract and the contract reaches the offering party after the time limit then in these cases usually the contract is considered to be accepted but in certain cases the offering party rejects to accept after the time limit has passed. To withdra w from the contract is not an easy task as it is against the principle of contracts and if a party wants to withdraw from a contract then the withdrawal must be made soon after the acceptance of the agreement (China, 1999). The contract law of the Republic of China is quite a lot in accordance to the principle of